Gut bugs disrupt cancer drugs – Nature.com

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MICROBIOME
Nature Reviews Microbiology (2022)
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The gut microbiome can alter the metabolism of anti-cancer drugs, potentially affecting their safety and efficacy, although the mechanisms are poorly understood. Now, Spanogiannopoulos et al. show that the efficacy of fluoropyrimidine chemotherapeutics is reduced by an enzyme expressed by gut microbiota.
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Spanogiannopoulos, P. et al. Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism. Nat. Microbiol. https://doi.org/10.1038/s41564-022-01226-5 (2022)
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Lindell, A. E., Zimmermann-Kogadeeva, M. & Patil, K. R. Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota. Nat. Rev. Microbiol. 20, 431–443 (2022)
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Nature Reviews Microbiology http://www.nature.com/nrmicro/
Michael Attwaters
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Correspondence to Michael Attwaters.
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Attwaters, M. Gut bugs disrupt cancer drugs. Nat Rev Microbiol (2022). https://doi.org/10.1038/s41579-022-00812-y
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Published: 12 October 2022
DOI: https://doi.org/10.1038/s41579-022-00812-y
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Nature Reviews Microbiology (Nat Rev Microbiol) ISSN 1740-1534 (online) ISSN 1740-1526 (print)
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