Twelfth version of living guideline issued for drugs for COVID-19 – Medical Xpress


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September 19, 2022

In the living guideline developed by the World Health Organization and published in The BMJ, recommendations on drug options for the treatment of COVID-19 have been updated.


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Arnav Agarwa, M.D., from McMaster University in Hamilton, Ontario, Canada, and colleagues produced the 12th version of the living guideline discussing the role of drugs in the treatment of COVID-19. New evidence was reviewed to update the earlier versions of these guidelines.
The authors updated recommendations for remdesivir, conditionally recommending its use in patients with severe COVID-19 and conditionally recommending against its use in critical COVID-19. The benefits of remdesivir are considered to be modest and of moderate certainty for key outcomes. Use of interleukin-6 receptor blockers (tocilizumab or sarilumab) may be combined with the Janus kinase inhibitor baricitinib, in addition to corticosteroids, for severe or critical COVID-19. Strong recommendations are provided against the use of sotrovimab and casirivimab-imdevimab for patients with nonsevere COVID-19, replacing the previous conditional recommendations for their use. There is a need for clinical trial evidence to confirm the clinical efficacy of new monoclonal antibodies that reliably neutralize circulating severe acute respiratory syndrome coronavirus 2 strains in vitro.
“Existing and emerging evidence demonstrates remaining uncertainties concerning treatment effects for all outcomes of importance to patients,” the authors write. “There is also a need for better evidence on values and preferences of with COVID-19.”


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More information: Abstract/Full Text

Journal information: British Medical Journal (BMJ)

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