Politics may have influenced use of ineffective COVID drugs – Harvard Gazette

Sign up for daily emails to get the latest Harvard news.
Harvard University
Officials, health policy, legal scholars discuss landmark suit targeting American manufacturers
Students reimagine uses for public land after Biden vows funds to redress harms done to urban areas when highway system was built
Counties with highest share of Republican voters saw dramatic increase in use of hydroxychloroquine and ivermectin
Americans should adjust rules, behaviors to reflect risk but also respect individual choices, analysts say
© 2022 The President and Fellows of Harvard College
The study found the spike in hydroxychloroquine and ivermectin prescriptions aligned with key political events.
iStock by Getty Images

February 18, 2022February 18, 2022
View all of The Coronavirus Update
Two treatments that have been shown to be ineffective against COVID-19 — hydroxychloroquine and ivermectin — were more heavily prescribed in the latter part of 2020 in U.S. counties with a higher Republican vote share in the 2020 presidential election, according to a new research letter co-authored by researchers from Harvard T.H. Chan School of Public Health.
The study was published online today in JAMA Internal Medicine.
“We’d all like to think of the health care system as basically non-partisan, but the COVID-19 pandemic may have started to chip away at this assumption,” said Michael Barnett, assistant professor of health policy and management and lead author of the study.
The study compared prescription rates for hydroxychloroquine and ivermectin with rates for two control medications, methotrexate sodium and albendazole, which are similar drugs but have not been proposed as COVID-19 treatments. Researchers looked at deidentified medical claims data from January 2019 through December 2020 from roughly 18.5 million adults across the U.S., as well as U.S. Census data and 2020 U.S. presidential election results.
Overall, hydroxychloroquine prescribing volume from June through December 2020 was roughly double what it had been the previous year, while ivermectin prescribing volume was seven-fold higher in December 2020 than it had been the previous year. In 2019, prescribing of hydroxychloroquine and ivermectin did not differ according to county Republican vote share. But that changed in 2020.
After June 2020 — coinciding with when the U.S. Food and Drug Administration revoked emergency use authorization for hydroxychloroquine — prescribing volume for the drug was significantly higher in counties with the highest Republican vote share as compared to counties with the lowest vote share.
As for ivermectin, prescribing volume was significantly higher in the highest versus lowest Republican vote share counties in December 2020 — 964 percent higher than 2019 overall prescribing volume. The spike aligned with several key events, such as the mid-November 2020 release of a now-retracted manuscript claiming that the drug was highly effective against COVID-19, and a widely publicized U.S. Senate hearing in early December that included testimony from a doctor promoting ivermectin as a COVID-19 treatment.
Neither of the control drugs had differences in overall prescribing volume or in prescribing by county Republican vote share.
The findings suggest that the prescribing of hydroxychloroquine and ivermectin could have been influenced by physician or patient political affiliation, the authors concluded. “This is the first evidence, to our knowledge, of such a political divide for a basic clinical decision like infection treatment or prevention,” said Barnett.
Harvard mourns the loss of Paul Farmer, cofounder of Partners In Health, who died Monday at age 62. In 2018, Farmer looked back at his work in global health care in a career-spanning interview with the Gazette.
Harvard-MIT study suggests infants view kissing or sharing food or utensils as social cues indicating close relationships
Students reimagine uses for public land after Biden vows funds to redress harms done to urban areas when highway system was built
View all of The Coronavirus Update
Risk assessment experts weigh in as Massachusetts and other states ease some COVID restrictions.
AP Photo/Steven Senne

source

Add a Comment

Your email address will not be published.